Rage Against the Mean: Perspective on measuring single-virus traits
We wrote a perspective on the need and recently developed approaches to study individual virus traits in the most numerous viruses on our planet (phages).
•
1 min read
A microscopic way to measure virus attachment
We replaced a (literally) century-old laborious assay to measure the attachment of viruses to bacteria. We developed a fast and efficient microscopy-approach to measure attachment …
•
1 min read
Evolution against a virus that attacks bacterial flagella
Phage χ can only infect E. coli with functional rotating flagella!! We studied what happens when bacteria are forced to evolve against this phage. We found: some bacteria swim …
•
1 min read
Synthetic bacteriophages
New England Biolabs (NEB) developed a Golden Gate method to engineer synthetic bacteriophages. I validated the expression of fluorescent proteins engineered into synthetic phage …
•
1 min read
Outsmarting Bacterial Evolution in Phage Therapy
Bacteria are great at evolving resistance to anything that we throw at them. This has caused antibiotic resistance crisis. We discuss smart approaches to use phages, viruses …
•
1 min read
Molecular Mechanisms of Mechanical Force Sensing by Bacterial Flagellar Motors
The flagellar motor in E. coli can sense mechanical forces. We discovered a mechanism involved in this sensing. See Tweetorial for a quick explanation.
•
1 min read
Single-cell Motility and Chemotaxis of Helicobacter pylori
H. pylori is a bacterium implicated in ulcers and cancers of the stomach. We studied their behavior in response to chemical gradients and the biophysical principles involved in …
•
1 min read
Role of Bacterial Flagella in Surface Sensing
Flagella are involved in the earliest stages of surface colonization by bacteria. We review the current understanding and challenges in Section 1 of an invited topical review.
•
1 min read
Orthogonal Imaging Chamber
The orthogonal cross‐sectional profiles (side-views) of fluorescent objects can be distorted when reconstructed from confocal image-slices (aka z-stacks). We designed a chamber to …
•
1 min read
Cell Nucleus Migration through Stiff Tissue-esque Scaffold
Intuition suggests that the stiff cell nucleus should be rupture-prone when forced to pass through obstacles. Instead, it behaves like an oil drop during migration, passing …
•
1 min read